PharmacyCodes



Tolterodinum [Inn-Latin] en es it fr

Tolterodinum [Inn-Latin] Brand names, Tolterodinum [Inn-Latin] Analogs

Tolterodinum [Inn-Latin] Brand Names Mixture

  • No information avaliable

Tolterodinum [Inn-Latin] Chemical_Formula

C22H31NO

Tolterodinum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic2/tolter.htm

Tolterodinum [Inn-Latin] fda sheet

Tolterodinum_[Inn-Latin] FDA

Tolterodinum [Inn-Latin] msds (material safety sheet)

Tolterodinum [Inn-Latin] Synthesis Reference

No information avaliable

Tolterodinum [Inn-Latin] Molecular Weight

325.488 g/mol

Tolterodinum [Inn-Latin] Melting Point

No information avaliable

Tolterodinum [Inn-Latin] H2O Solubility

No information avaliable

Tolterodinum [Inn-Latin] State

Solid

Tolterodinum [Inn-Latin] LogP

6.076

Tolterodinum [Inn-Latin] Dosage Forms

Capsule (sustained-release)

Tolterodinum [Inn-Latin] Indication

For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).

Tolterodinum [Inn-Latin] Pharmacology

Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Tolterodine has a pronounced effect on bladder function. The main effects of tolterodine are an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, consistent with an antimuscarinic action on the lower urinary tract.

Tolterodinum [Inn-Latin] Absorption

No information avaliable

Tolterodinum [Inn-Latin] side effects and Toxicity

No information avaliable

Tolterodinum [Inn-Latin] Patient Information

No information avaliable

Tolterodinum [Inn-Latin] Organisms Affected

Humans and other mammals